Beilstein J. Org. Chem.2021,17, 2390–2398, doi:10.3762/bjoc.17.156
analyses. The absolute configuration of the threonine residue in compounds 1–5 was determined by Marfey analysis. The antimicrobial evaluation of compound 4 exhibited the most potent activity against vancomycin-sensitiveEnterococcusfaecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to
; pseudomonine; Pseudomonas sp.; vancomycin-sensitiveEnterococcusfaecium; Introduction
The introduction of antimicrobial drugs in the mid-20th century has had an unprecedented positive impact on human health, but the current threat of multiple drug resistance may well roll back all these past achievements [1
][37], together with their antimicrobial activities against vancomycin-sensitiveEnterococcusfaecium VS144754 and Mycobacterium tuberculosis strain H37Rv. A plausible biosynthetic hypothesis is proposed towards the new compounds 1–5.
Results and Discussion
The preliminary LC–MS analysis of the
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Graphical Abstract
Figure 1:
Structures of the new phenolic siderophores 1–5, pseudomonine (6), and salicylic acid (7).